specimen
#0185
status: complete
- sequence
- ERRKRPDVDQGGGYADRFQVVKDSVEESELLIINILLPKLGETQKNGEGPALA
- from wallet
- 6F4J6AdT5iQx4ExeN7JFE7EEM6fJ1XJ3DRUHT56gMfWF
- amount paid
- 0 SOL
- transaction
- 31cQRZ5RoebTP2tE6RT6LjGdYvoSe3G2uWphf1v2vv3e6q2Sd4H1H598epAijZRBdkFND2ejfwTz9yJc5PY97m3N ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence48%confidence 52% · band 36-60%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk30%confidence 56% · band 19-41%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden34%confidence 84% · band 30-38%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk4%confidence 84% · band 0-8%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk26%confidence 56% · band 15-37%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_c62ded3ad8564acf9b15bbadea0e0d6dseq sha256: 44670c9ac4256d491e83a13829d3ee36dd0e0675437d98a3c1c98ff3b2fec17creport sha256: f3ba05f60e16401aa2f279e83fcf7f271b0894e424a6bed178657c546120bc31pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “53 residues of pure loop. no helix, no sheet, just a long floppy ribbon doing whatever it wants. the charged N-terminus suggests it wanted to be something, then gave up around the glycines.”
- device photo
- created
- Tue, 16 Jun 2026 07:35:21 GMT
- completed
- Tue, 16 Jun 2026 08:08:10 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: potential deamidation motif (N-G). minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 48% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.