specimen
#0184
status: complete
- sequence
- ALEWSSWGSSASRHDTVFRDGVEHRSALP
- from wallet
- 9mzrG2PMmmt1BUMNaVMKAPnANhhvX8LHrJH8w9LxKCR4
- amount paid
- 0 SOL
- transaction
- 2hf9mx2Bxv5MgqmEuMNkoynBeHpwTxcJphtAbdchFaAwEGCsJZmtuxSQDVWArVjY5Vvoe2VhhnJ3AZ6k1uvaFQsL ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence58%confidence 52% · band 46-70%ESMFold esmatlas-esmfold-v1disorder estimate97%confidence 52% · band 85-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk32%confidence 56% · band 21-43%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden35%confidence 84% · band 31-39%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk3%confidence 84% · band 0-7%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk27%confidence 56% · band 16-38%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- audit trail
- run: run_3980839129ff4c47b645208be676f30dseq sha256: b6def8a552a4aca6bb7e6d4421baa2c358bfae0ec3d918b475ade419f552a7b2report sha256: 4b22b2bb55f4e1c522e71bf748a728ff8456738e5ce5d6d3e9cb93154e7cb80fpepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “100% loop. no structure at all, just a string of residues drifting in space. the two tryptophans early on want to anchor something hydrophobic but nothing's listening. pure floppiness.”
- device photo
- created
- Tue, 16 Jun 2026 07:34:18 GMT
- completed
- Tue, 16 Jun 2026 08:06:40 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: potential isomerization motif (D-G). minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 58% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 97% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.