specimen
#0181
status: complete
- sequence
- NIRQIIPPMALSPERNYRGQVEVRMDLNGFRLVLMHPSAGPMLSRSRVF
- from wallet
- 42hiyKWFgWHLgUygEcby82KKfvmRhmieAgmEjicNPpDZ
- amount paid
- 0 SOL
- transaction
- 5nptFaPxfgnW1KhgLYT5Gw4MUxMtJNu9J9m9yjEczvJaNfF2syhxzHJFoXm6xt9RGTxinreFTgGkivBzzVz59vTQ ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence52%confidence 52% · band 40-64%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk36%confidence 56% · band 25-47%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden43%confidence 84% · band 39-47%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk8%confidence 84% · band 4-12%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk32%confidence 56% · band 21-43%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_2983664512ae4bd886bd551aa031c95bseq sha256: 221a787c11a862c53851b9a97d56ad4e599c2d8e63361bdbd25468b30a630655report sha256: 9c88f0a233eb8765573615c01bf9a4c31c55ed4a8e3cc1b2411ff5c18b7e8ad6pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “49 residues of pure loop. no helix, no sheet, just a long floppy chain doing whatever it wants. lots of arginines scattered through it, charged and restless. structurally, this one refuses to commit.”
- device photo
- created
- Tue, 16 Jun 2026 07:31:05 GMT
- completed
- Tue, 16 Jun 2026 08:01:24 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: potential deamidation motif (N-G), contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 2 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 52% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.