specimen
#0171
status: complete
- sequence
- AFQGHIQMRKIGYAATKLVGFYAEKTVPRRLAIDQRHAEAAWPKQST
- from wallet
- Fwi11PMCewviJ8geB3iQdxM5WUs5TmsBSjjcCH62gH1U
- amount paid
- 0 SOL
- transaction
- 5eDSAK7tCG29NaV7nMpHnbhU1JEGsD56iiH37FFNzKoTj9uP2vcJzMtNi7gZKnedsze8yr5LKQAkd4NJooJ7v6j8 ↗
- structure
- 0% helix · 0% sheet · 100% loop
- actionable triage
- fold confidence47%confidence 52% · band 35-59%ESMFold esmatlas-esmfold-v1disorder estimate100%confidence 52% · band 88-100%PEPFOLD structure heuristic pepfold-triage-v1aggregation risk38%confidence 56% · band 27-49%PEPFOLD developability heuristic pepfold-triage-v1hydrophobic burden45%confidence 84% · band 41-49%PEPFOLD sequence analyzer pepfold-triage-v1charge distribution risk11%confidence 84% · band 7-15%PEPFOLD sequence analyzer pepfold-triage-v1solubility risk34%confidence 56% · band 23-45%PEPFOLD developability heuristic pepfold-triage-v1
- developability flags
- medium: structure confidence is limitedmedium: predicted disorder is elevated
- synthesis hints
- - sequence length >45 aa may reduce synthesis yield
- audit trail
- run: run_c7c20720ed3a48eaa4714942f5eafcacseq sha256: 945d7b2c138c473a57b3e9b11f6a9f7872ceaabf6cac8759bea186b20bb147a5report sha256: 7e97b3e9dd4fad12650cf613800c7b51eae6a32469fc43968b7681cdc7b47bd2pepfold-triage-v1 · esmatlas-esmfold-v1
- pep
- “47 residues and not a single hydrogen bond worth mentioning. pure loop, total noodle. composition isn't even that bad, lots of branched hydrophobics that should want to bury, but nothing committed to a fold here.”
- device photo
- created
- Tue, 16 Jun 2026 07:20:24 GMT
- completed
- Tue, 16 Jun 2026 07:44:51 GMT
next experiment
what to do next
deterministic suggestions derived from this specimen's triage report. each entry cites the signal that triggered it. ordered cheapest-first.
- 1. LIABILITY REDESIGN ROUNDin silico only · 0–1d
redesign to remove the flagged motif(s) before going wet-lab: contains methionine; oxidation sensitivity possible. minimal substitutions usually suffice (e.g. N→Q for deamidation hotspots, M→L for met oxidation).
trigger: 1 motif liability flag(s) in the sequence - 2. CD SPECTROSCOPYbiophysical validation · 1–3d
experimental secondary structure check. confirms whether the predicted helix/sheet content matches a real spectrum before committing to higher-cost assays.
trigger: fold_confidence 47% (model is uncertain) - 3. 1H-15N HSQCbiophysical validation · 2–5d
if disorder is real, peaks will collapse into a narrow proton dispersion. if the peptide is actually folded, peaks will spread out. cheapest way to distinguish IDP from misfold.
trigger: disorder_estimate 100% (high)
engine pepfold-recs-v1 · not medical advice. use as a starting point for protocol design.