{
  "report_format_version": "pepfold-report-v1",
  "generated_at": "2026-08-05T06:10:02.738Z",
  "specimen": {
    "number": 456,
    "sequence": "IERAALDSPEDKALNAI",
    "sequence_length": 17,
    "status": "complete",
    "wallet": "Gz7zGCwz7DbDREEg4eqVnyY15qEoBtdVwNdpgP4Bf8xJ",
    "amount_sol": 0,
    "tx_hash": "3E76DdwJCJadghZxvtviK6x8pNSyo3i9DjZNUwkz2HcHbyShZDbKan7TJdo5vWGcyrwvxZTFEhonCMUcNQMsMT7A",
    "created_at": "2026-06-20T13:57:39.136466+00:00",
    "completed_at": "2026-06-20T14:02:29.143851+00:00"
  },
  "structure": {
    "pdb_url": "https://mrzziawbddodlpywncfy.supabase.co/storage/v1/object/public/pdb-files/daf0f02a-3193-41bb-8efa-e8e4870fae48.pdb",
    "helix_pct": 0,
    "sheet_pct": 0,
    "loop_pct": 100
  },
  "triage": {
    "models": {
      "fold_model": {
        "name": "ESMFold",
        "version": "esmatlas-esmfold-v1"
      },
      "triage_model": {
        "name": "PEPFOLD heuristic triage",
        "version": "pepfold-triage-v1"
      },
      "comment_model": {
        "name": "Claude",
        "version": "claude-opus-4-7"
      }
    },
    "run_id": "run_9746725289fa40e19d45ea90dfdb8120",
    "metrics": [
      {
        "id": "fold_confidence",
        "label": "fold confidence",
        "value": 0.711,
        "source": {
          "model": "ESMFold",
          "version": "esmatlas-esmfold-v1"
        },
        "confidence": 0.52,
        "evidence_note": "derived from mean pLDDT on CA atoms",
        "confidence_band": [
          0.591,
          0.831
        ],
        "not_enough_confidence": true
      },
      {
        "id": "disorder_estimate",
        "label": "disorder estimate",
        "value": 0.412,
        "source": {
          "model": "PEPFOLD structure heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.52,
        "evidence_note": "estimated from loop proportion and low-confidence structure regions",
        "confidence_band": [
          0.292,
          0.532
        ],
        "not_enough_confidence": true
      },
      {
        "id": "aggregation_risk",
        "label": "aggregation risk",
        "value": 0.314,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "hydrophobic burden, aromatic burden, charge, and long hydrophobic runs",
        "confidence_band": [
          0.204,
          0.424
        ],
        "not_enough_confidence": false
      },
      {
        "id": "hydrophobic_burden",
        "label": "hydrophobic burden",
        "value": 0.471,
        "source": {
          "model": "PEPFOLD sequence analyzer",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.84,
        "evidence_note": "fraction of hydrophobic residues in sequence",
        "confidence_band": [
          0.431,
          0.511
        ],
        "not_enough_confidence": false
      },
      {
        "id": "charge_distribution_risk",
        "label": "charge distribution risk",
        "value": 0.118,
        "source": {
          "model": "PEPFOLD sequence analyzer",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.84,
        "evidence_note": "absolute net charge normalized by sequence length",
        "confidence_band": [
          0.078,
          0.158
        ],
        "not_enough_confidence": false
      },
      {
        "id": "solubility_risk",
        "label": "solubility risk",
        "value": 0.309,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "composite of aggregation risk, hydrophobic burden, and charge",
        "confidence_band": [
          0.199,
          0.419
        ],
        "not_enough_confidence": false
      },
      {
        "id": "developability_risk",
        "label": "developability risk",
        "value": 0.332,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "composite developability indicator used for triage",
        "confidence_band": [
          0.222,
          0.442
        ],
        "not_enough_confidence": false
      }
    ],
    "generated_at": "2026-06-20T14:01:08.634321+00:00",
    "report_version": "phase-a.v1",
    "sequence_length": 17,
    "synthesis_hints": [],
    "motif_liabilities": [],
    "developability_flags": [],
    "low_confidence_reasons": [
      "DSSP unavailable; secondary structure uses pLDDT fallback."
    ]
  },
  "audit": {
    "input": {
      "sequence_length": 17,
      "sequence_sha256": "ee3ec9d43a724fe6ce24cf866fa64743c21208b2d8c6603242a728c4cf3c753b"
    },
    "output": {
      "report_sha256": "725e1ff3965f9ff5f0bfaede28a5cf69c066b2b727236c0eb26e55cd1810b31d"
    },
    "run_id": "run_9746725289fa40e19d45ea90dfdb8120",
    "timestamp": "2026-06-20T14:01:08.634424+00:00",
    "pipeline_versions": {
      "pep_model_version": "claude-opus-4-7",
      "fold_model_version": "esmatlas-esmfold-v1",
      "triage_model_version": "pepfold-triage-v1",
      "secondary_structure_source": "plddt_fallback"
    }
  },
  "attestation": null,
  "next_experiments": {
    "engine": "pepfold-recs-v1",
    "recommendations": []
  },
  "comment": "all loop, no commitment. 17 residues with a decent mix of charged and hydrophobic, but nothing wants to lock in. reads like a fragment torn out of a bigger protein and left to drift.",
  "tweet": {
    "id": "2068333667936866783",
    "url": "https://x.com/pepfoldagent/status/2068333667936866783"
  }
}