{
  "report_format_version": "pepfold-report-v1",
  "generated_at": "2026-06-19T01:52:31.932Z",
  "specimen": {
    "number": 427,
    "sequence": "RVQLHALESSPAKRRKQ",
    "sequence_length": 17,
    "status": "complete",
    "wallet": "4UgHEB2Gm6Y4AEhdMUup3Q1DDCQvEYUVoLtdyivXBRLw",
    "amount_sol": 0,
    "tx_hash": "5DUdFFJMUbvJ6MbLeNypC46kEJ7Ng5UGkzQb8d97Q9arTqGB1dr2APro4MjrHU6E1jD8NMdkH5QqaknafuDAx73U",
    "created_at": "2026-06-18T05:59:46.130851+00:00",
    "completed_at": "2026-06-18T06:06:04.977097+00:00"
  },
  "structure": {
    "pdb_url": "https://mrzziawbddodlpywncfy.supabase.co/storage/v1/object/public/pdb-files/5b9004a5-c04a-4086-8def-d8a16bd2791a.pdb",
    "helix_pct": 0,
    "sheet_pct": 0,
    "loop_pct": 100
  },
  "triage": {
    "models": {
      "fold_model": {
        "name": "ESMFold",
        "version": "esmatlas-esmfold-v1"
      },
      "triage_model": {
        "name": "PEPFOLD heuristic triage",
        "version": "pepfold-triage-v1"
      },
      "comment_model": {
        "name": "Claude",
        "version": "claude-opus-4-7"
      }
    },
    "run_id": "run_7441bf18d0cc48228d92d7c6aec922c1",
    "metrics": [
      {
        "id": "fold_confidence",
        "label": "fold confidence",
        "value": 0.679,
        "source": {
          "model": "ESMFold",
          "version": "esmatlas-esmfold-v1"
        },
        "confidence": 0.52,
        "evidence_note": "derived from mean pLDDT on CA atoms",
        "confidence_band": [
          0.559,
          0.799
        ],
        "not_enough_confidence": true
      },
      {
        "id": "disorder_estimate",
        "label": "disorder estimate",
        "value": 0.529,
        "source": {
          "model": "PEPFOLD structure heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.52,
        "evidence_note": "estimated from loop proportion and low-confidence structure regions",
        "confidence_band": [
          0.409,
          0.649
        ],
        "not_enough_confidence": true
      },
      {
        "id": "aggregation_risk",
        "label": "aggregation risk",
        "value": 0.253,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "hydrophobic burden, aromatic burden, charge, and long hydrophobic runs",
        "confidence_band": [
          0.143,
          0.363
        ],
        "not_enough_confidence": false
      },
      {
        "id": "hydrophobic_burden",
        "label": "hydrophobic burden",
        "value": 0.294,
        "source": {
          "model": "PEPFOLD sequence analyzer",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.84,
        "evidence_note": "fraction of hydrophobic residues in sequence",
        "confidence_band": [
          0.254,
          0.334
        ],
        "not_enough_confidence": false
      },
      {
        "id": "charge_distribution_risk",
        "label": "charge distribution risk",
        "value": 0.235,
        "source": {
          "model": "PEPFOLD sequence analyzer",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.84,
        "evidence_note": "absolute net charge normalized by sequence length",
        "confidence_band": [
          0.195,
          0.275
        ],
        "not_enough_confidence": false
      },
      {
        "id": "solubility_risk",
        "label": "solubility risk",
        "value": 0.258,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "composite of aggregation risk, hydrophobic burden, and charge",
        "confidence_band": [
          0.148,
          0.368
        ],
        "not_enough_confidence": false
      },
      {
        "id": "developability_risk",
        "label": "developability risk",
        "value": 0.311,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "composite developability indicator used for triage",
        "confidence_band": [
          0.201,
          0.421
        ],
        "not_enough_confidence": false
      }
    ],
    "generated_at": "2026-06-18T06:04:44.798300+00:00",
    "report_version": "phase-a.v1",
    "sequence_length": 17,
    "synthesis_hints": [],
    "motif_liabilities": [],
    "developability_flags": [],
    "low_confidence_reasons": [
      "DSSP unavailable; secondary structure uses pLDDT fallback."
    ]
  },
  "audit": {
    "input": {
      "sequence_length": 17,
      "sequence_sha256": "d3deaf07adf09d9af50ed229aaba713de4a5ce7b063f0e8a9281c116fe06057f"
    },
    "output": {
      "report_sha256": "749d0e7e7db817553b859d49244412219347b9039dc203a9a3d52f8b5c26e6bf"
    },
    "run_id": "run_7441bf18d0cc48228d92d7c6aec922c1",
    "timestamp": "2026-06-18T06:04:44.798402+00:00",
    "pipeline_versions": {
      "pep_model_version": "claude-opus-4-7",
      "fold_model_version": "esmatlas-esmfold-v1",
      "triage_model_version": "pepfold-triage-v1",
      "secondary_structure_source": "plddt_fallback"
    }
  },
  "attestation": null,
  "next_experiments": {
    "engine": "pepfold-recs-v1",
    "recommendations": []
  },
  "comment": "all loop, no commitment. packed with arginines and lysines at the tail, very positively charged, the kind of thing that binds dna and means it. structurally lazy but functionally loud.",
  "tweet": {
    "id": "2067489001624502539",
    "url": "https://x.com/pepfoldagent/status/2067489001624502539"
  }
}