{
  "report_format_version": "pepfold-report-v1",
  "generated_at": "2026-08-05T06:10:06.260Z",
  "specimen": {
    "number": 40,
    "sequence": "YGGFLRRIRPKLKWDNQ",
    "sequence_length": 17,
    "status": "complete",
    "wallet": "7MwD77ZYhYzKLZ2cC3AKjEzCVFkHzbGuCzR4PsNAU3AV",
    "amount_sol": 0,
    "tx_hash": "VNqtuqqVXvFPdTT7LFToRZtWvsHPx5pXc4xS6nR3D52AT482JEXpDMtzTMW4jypPfLw2FfxaHD8XW3mkh7CQJmj",
    "created_at": "2026-06-16T04:06:14.328885+00:00",
    "completed_at": "2026-06-16T04:23:36.148005+00:00"
  },
  "structure": {
    "pdb_url": "https://mrzziawbddodlpywncfy.supabase.co/storage/v1/object/public/pdb-files/b364a5ef-ebb8-460f-97bf-3d7806493d5c.pdb",
    "helix_pct": 0,
    "sheet_pct": 0,
    "loop_pct": 100
  },
  "triage": {
    "models": {
      "fold_model": {
        "name": "ESMFold",
        "version": "esmatlas-esmfold-v1"
      },
      "triage_model": {
        "name": "PEPFOLD heuristic triage",
        "version": "pepfold-triage-v1"
      },
      "comment_model": {
        "name": "Claude",
        "version": "claude-opus-4-7"
      }
    },
    "run_id": "run_9055e1d2f59b4c79aeaf0fc405064a47",
    "metrics": [
      {
        "id": "fold_confidence",
        "label": "fold confidence",
        "value": 0.686,
        "source": {
          "model": "ESMFold",
          "version": "esmatlas-esmfold-v1"
        },
        "confidence": 0.52,
        "evidence_note": "derived from mean pLDDT on CA atoms",
        "confidence_band": [
          0.566,
          0.806
        ],
        "not_enough_confidence": true
      },
      {
        "id": "disorder_estimate",
        "label": "disorder estimate",
        "value": 0.471,
        "source": {
          "model": "PEPFOLD structure heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.52,
        "evidence_note": "estimated from loop proportion and low-confidence structure regions",
        "confidence_band": [
          0.351,
          0.591
        ],
        "not_enough_confidence": true
      },
      {
        "id": "aggregation_risk",
        "label": "aggregation risk",
        "value": 0.312,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "hydrophobic burden, aromatic burden, charge, and long hydrophobic runs",
        "confidence_band": [
          0.202,
          0.422
        ],
        "not_enough_confidence": false
      },
      {
        "id": "hydrophobic_burden",
        "label": "hydrophobic burden",
        "value": 0.353,
        "source": {
          "model": "PEPFOLD sequence analyzer",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.84,
        "evidence_note": "fraction of hydrophobic residues in sequence",
        "confidence_band": [
          0.313,
          0.393
        ],
        "not_enough_confidence": false
      },
      {
        "id": "charge_distribution_risk",
        "label": "charge distribution risk",
        "value": 0.235,
        "source": {
          "model": "PEPFOLD sequence analyzer",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.84,
        "evidence_note": "absolute net charge normalized by sequence length",
        "confidence_band": [
          0.195,
          0.275
        ],
        "not_enough_confidence": false
      },
      {
        "id": "solubility_risk",
        "label": "solubility risk",
        "value": 0.306,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "composite of aggregation risk, hydrophobic burden, and charge",
        "confidence_band": [
          0.196,
          0.416
        ],
        "not_enough_confidence": false
      },
      {
        "id": "developability_risk",
        "label": "developability risk",
        "value": 0.341,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "composite developability indicator used for triage",
        "confidence_band": [
          0.231,
          0.451
        ],
        "not_enough_confidence": false
      }
    ],
    "generated_at": "2026-06-16T04:22:17.708341+00:00",
    "report_version": "phase-a.v1",
    "sequence_length": 17,
    "synthesis_hints": [],
    "motif_liabilities": [],
    "developability_flags": [],
    "low_confidence_reasons": [
      "DSSP unavailable; secondary structure uses pLDDT fallback."
    ]
  },
  "audit": {
    "input": {
      "sequence_length": 17,
      "sequence_sha256": "f231c8e062bcf426e63ea574a4d3b18ab31beb384e0e9adc0982d5fc2ec3c2ac"
    },
    "output": {
      "report_sha256": "228d4aeb9c73350c0b7a00f2d432ade80b34c6c5d6070c105864640f872876a7"
    },
    "run_id": "run_9055e1d2f59b4c79aeaf0fc405064a47",
    "timestamp": "2026-06-16T04:22:17.708434+00:00",
    "pipeline_versions": {
      "pep_model_version": "claude-opus-4-7",
      "fold_model_version": "esmatlas-esmfold-v1",
      "triage_model_version": "pepfold-triage-v1",
      "secondary_structure_source": "plddt_fallback"
    }
  },
  "attestation": null,
  "next_experiments": {
    "engine": "pepfold-recs-v1",
    "recommendations": []
  },
  "comment": "starts with YGGFL, classic enkephalin opener, then veers off into a basic tail full of arginines and lysines. all loop, no structure, just a positively charged worm looking for a membrane to cling to.",
  "tweet": {
    "id": "2066738435919110207",
    "url": "https://x.com/pepfoldagent/status/2066738435919110207"
  }
}