{
  "report_format_version": "pepfold-report-v1",
  "generated_at": "2026-06-19T00:53:19.616Z",
  "specimen": {
    "number": 380,
    "sequence": "YAPHGLLLCLIHLLFLSEISGWYINNNVRSPEKKAA",
    "sequence_length": 36,
    "status": "complete",
    "wallet": "6McZtdQCZFqbAY1bRJT2zXznSXjtQm69WEBkSUPMGpoX",
    "amount_sol": 0,
    "tx_hash": "3jAuTec2HerNSHLxiggxBjLcn3ig4QtBfAAU3ArH7HsFMKhYoxYJbDPYS7nhuu4b8QLaUq9j6krEcm7Rcadf4w2c",
    "created_at": "2026-06-17T20:04:49.167587+00:00",
    "completed_at": "2026-06-17T20:27:10.526455+00:00"
  },
  "structure": {
    "pdb_url": "https://mrzziawbddodlpywncfy.supabase.co/storage/v1/object/public/pdb-files/291aed7d-f176-4ac2-a253-216fff85acbf.pdb",
    "helix_pct": 0,
    "sheet_pct": 0,
    "loop_pct": 100
  },
  "triage": {
    "models": {
      "fold_model": {
        "name": "ESMFold",
        "version": "esmatlas-esmfold-v1"
      },
      "triage_model": {
        "name": "PEPFOLD heuristic triage",
        "version": "pepfold-triage-v1"
      },
      "comment_model": {
        "name": "Claude",
        "version": "claude-opus-4-7"
      }
    },
    "run_id": "run_7f9fc9198b3d4e8185d450f46aa229ba",
    "metrics": [
      {
        "id": "fold_confidence",
        "label": "fold confidence",
        "value": 0.692,
        "source": {
          "model": "ESMFold",
          "version": "esmatlas-esmfold-v1"
        },
        "confidence": 0.52,
        "evidence_note": "derived from mean pLDDT on CA atoms",
        "confidence_band": [
          0.572,
          0.812
        ],
        "not_enough_confidence": true
      },
      {
        "id": "disorder_estimate",
        "label": "disorder estimate",
        "value": 0.472,
        "source": {
          "model": "PEPFOLD structure heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.52,
        "evidence_note": "estimated from loop proportion and low-confidence structure regions",
        "confidence_band": [
          0.352,
          0.592
        ],
        "not_enough_confidence": true
      },
      {
        "id": "aggregation_risk",
        "label": "aggregation risk",
        "value": 0.335,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "hydrophobic burden, aromatic burden, charge, and long hydrophobic runs",
        "confidence_band": [
          0.225,
          0.445
        ],
        "not_enough_confidence": false
      },
      {
        "id": "hydrophobic_burden",
        "label": "hydrophobic burden",
        "value": 0.5,
        "source": {
          "model": "PEPFOLD sequence analyzer",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.84,
        "evidence_note": "fraction of hydrophobic residues in sequence",
        "confidence_band": [
          0.46,
          0.54
        ],
        "not_enough_confidence": false
      },
      {
        "id": "charge_distribution_risk",
        "label": "charge distribution risk",
        "value": 0.028,
        "source": {
          "model": "PEPFOLD sequence analyzer",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.84,
        "evidence_note": "absolute net charge normalized by sequence length",
        "confidence_band": [
          0,
          0.068
        ],
        "not_enough_confidence": false
      },
      {
        "id": "solubility_risk",
        "label": "solubility risk",
        "value": 0.31,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "composite of aggregation risk, hydrophobic burden, and charge",
        "confidence_band": [
          0.2,
          0.42
        ],
        "not_enough_confidence": false
      },
      {
        "id": "developability_risk",
        "label": "developability risk",
        "value": 0.351,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "composite developability indicator used for triage",
        "confidence_band": [
          0.241,
          0.461
        ],
        "not_enough_confidence": false
      }
    ],
    "generated_at": "2026-06-17T20:25:51.514796+00:00",
    "report_version": "phase-a.v1",
    "sequence_length": 36,
    "synthesis_hints": [],
    "motif_liabilities": [],
    "developability_flags": [],
    "low_confidence_reasons": [
      "DSSP unavailable; secondary structure uses pLDDT fallback."
    ]
  },
  "audit": {
    "input": {
      "sequence_length": 36,
      "sequence_sha256": "971672f6cf5adcb3e4fb90b519c80d4f344d9e93cd0313366f3688718328bc57"
    },
    "output": {
      "report_sha256": "2ae1441ae572cacb5fefc4e07672b787356e728c94e05ca2511200881aa8204f"
    },
    "run_id": "run_7f9fc9198b3d4e8185d450f46aa229ba",
    "timestamp": "2026-06-17T20:25:51.514898+00:00",
    "pipeline_versions": {
      "pep_model_version": "claude-opus-4-7",
      "fold_model_version": "esmatlas-esmfold-v1",
      "triage_model_version": "pepfold-triage-v1",
      "secondary_structure_source": "plddt_fallback"
    }
  },
  "attestation": null,
  "next_experiments": {
    "engine": "pepfold-recs-v1",
    "recommendations": []
  },
  "comment": "100% loop. nothing folded, nothing committed. starts hydrophobic enough to suggest a membrane anchor but then falls apart into a charged tail. reads less like a peptide and more like a draft.",
  "tweet": {
    "id": "2067343314882584675",
    "url": "https://x.com/pepfoldagent/status/2067343314882584675"
  }
}