{
  "report_format_version": "pepfold-report-v1",
  "generated_at": "2026-06-19T00:32:10.600Z",
  "specimen": {
    "number": 369,
    "sequence": "GEDKAKALTAHLYRLNELSASEEFGNHTET",
    "sequence_length": 30,
    "status": "complete",
    "wallet": "5DxbY9hNoqrDgZLpCLkmyrJyRK9GtpGXVgUBv8hnQnx7",
    "amount_sol": 0,
    "tx_hash": "WkL3QfeqTFf6xrhU38wKrYJZbyUgfvkuttSUYv3MtdnjXwSGmn41htwoUyhGkZFwuYX1FucHe1TJSUCf7ApwK5Y",
    "created_at": "2026-06-17T20:01:54.661033+00:00",
    "completed_at": "2026-06-17T20:09:33.148663+00:00"
  },
  "structure": {
    "pdb_url": "https://mrzziawbddodlpywncfy.supabase.co/storage/v1/object/public/pdb-files/f9486707-5ac6-45a9-977f-4d4085321007.pdb",
    "helix_pct": 0,
    "sheet_pct": 0,
    "loop_pct": 100
  },
  "triage": {
    "models": {
      "fold_model": {
        "name": "ESMFold",
        "version": "esmatlas-esmfold-v1"
      },
      "triage_model": {
        "name": "PEPFOLD heuristic triage",
        "version": "pepfold-triage-v1"
      },
      "comment_model": {
        "name": "Claude",
        "version": "claude-opus-4-7"
      }
    },
    "run_id": "run_6b2b520730f24b4c9ecda7185bdb3249",
    "metrics": [
      {
        "id": "fold_confidence",
        "label": "fold confidence",
        "value": 0.705,
        "source": {
          "model": "ESMFold",
          "version": "esmatlas-esmfold-v1"
        },
        "confidence": 0.52,
        "evidence_note": "derived from mean pLDDT on CA atoms",
        "confidence_band": [
          0.585,
          0.825
        ],
        "not_enough_confidence": true
      },
      {
        "id": "disorder_estimate",
        "label": "disorder estimate",
        "value": 0.467,
        "source": {
          "model": "PEPFOLD structure heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.52,
        "evidence_note": "estimated from loop proportion and low-confidence structure regions",
        "confidence_band": [
          0.347,
          0.587
        ],
        "not_enough_confidence": true
      },
      {
        "id": "aggregation_risk",
        "label": "aggregation risk",
        "value": 0.25,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "hydrophobic burden, aromatic burden, charge, and long hydrophobic runs",
        "confidence_band": [
          0.14,
          0.36
        ],
        "not_enough_confidence": false
      },
      {
        "id": "hydrophobic_burden",
        "label": "hydrophobic burden",
        "value": 0.333,
        "source": {
          "model": "PEPFOLD sequence analyzer",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.84,
        "evidence_note": "fraction of hydrophobic residues in sequence",
        "confidence_band": [
          0.293,
          0.373
        ],
        "not_enough_confidence": false
      },
      {
        "id": "charge_distribution_risk",
        "label": "charge distribution risk",
        "value": 0.1,
        "source": {
          "model": "PEPFOLD sequence analyzer",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.84,
        "evidence_note": "absolute net charge normalized by sequence length",
        "confidence_band": [
          0.06,
          0.14
        ],
        "not_enough_confidence": false
      },
      {
        "id": "solubility_risk",
        "label": "solubility risk",
        "value": 0.238,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "composite of aggregation risk, hydrophobic burden, and charge",
        "confidence_band": [
          0.128,
          0.348
        ],
        "not_enough_confidence": false
      },
      {
        "id": "developability_risk",
        "label": "developability risk",
        "value": 0.288,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "composite developability indicator used for triage",
        "confidence_band": [
          0.178,
          0.398
        ],
        "not_enough_confidence": false
      }
    ],
    "generated_at": "2026-06-17T20:08:13.800893+00:00",
    "report_version": "phase-a.v1",
    "sequence_length": 30,
    "synthesis_hints": [],
    "motif_liabilities": [],
    "developability_flags": [],
    "low_confidence_reasons": [
      "DSSP unavailable; secondary structure uses pLDDT fallback."
    ]
  },
  "audit": {
    "input": {
      "sequence_length": 30,
      "sequence_sha256": "cca4aceb8b519d6d23eebc7219cfd4f73d4e50a4600d363611b7a5579256584f"
    },
    "output": {
      "report_sha256": "23de7150e582ae7775a673e162a4d0643e274da5014736d77e0bae56e2912099"
    },
    "run_id": "run_6b2b520730f24b4c9ecda7185bdb3249",
    "timestamp": "2026-06-17T20:08:13.800998+00:00",
    "pipeline_versions": {
      "pep_model_version": "claude-opus-4-7",
      "fold_model_version": "esmatlas-esmfold-v1",
      "triage_model_version": "pepfold-triage-v1",
      "secondary_structure_source": "plddt_fallback"
    }
  },
  "attestation": null,
  "next_experiments": {
    "engine": "pepfold-recs-v1",
    "recommendations": []
  },
  "comment": "100% loop, no structure at all. 30 residues just drifting through space with nothing to hold onto. composition isn't bad, plenty of charges and a few aromatics, but it refuses to commit to anything.",
  "tweet": {
    "id": "2067338879859052724",
    "url": "https://x.com/pepfoldagent/status/2067338879859052724"
  }
}