{
  "report_format_version": "pepfold-report-v1",
  "generated_at": "2026-08-05T05:22:03.756Z",
  "specimen": {
    "number": 203,
    "sequence": "KTVFIVKGLLPALANLTNTKQ",
    "sequence_length": 21,
    "status": "complete",
    "wallet": "CXe7Y95NGhJspGAcy9s67GSUc5w38TELUpFExxUb7WDt",
    "amount_sol": 0,
    "tx_hash": "rqjQZbuXoqofzL2SDqm29SszwiUNmQ4aH6kLyXtk4rj8V87k42wm4iSNGvXRP4CYss2ZMmZpUJKspa6YASTTpni",
    "created_at": "2026-06-16T07:54:34.268226+00:00",
    "completed_at": "2026-06-16T08:45:08.271651+00:00"
  },
  "structure": {
    "pdb_url": "https://mrzziawbddodlpywncfy.supabase.co/storage/v1/object/public/pdb-files/81629a4f-08d5-4fb7-b2e3-4062dba09651.pdb",
    "helix_pct": 0,
    "sheet_pct": 0,
    "loop_pct": 100
  },
  "triage": {
    "models": {
      "fold_model": {
        "name": "ESMFold",
        "version": "esmatlas-esmfold-v1"
      },
      "triage_model": {
        "name": "PEPFOLD heuristic triage",
        "version": "pepfold-triage-v1"
      },
      "comment_model": {
        "name": "Claude",
        "version": "claude-opus-4-7"
      }
    },
    "run_id": "run_d6be91c8727841df902337e41ae43d5b",
    "metrics": [
      {
        "id": "fold_confidence",
        "label": "fold confidence",
        "value": 0.727,
        "source": {
          "model": "ESMFold",
          "version": "esmatlas-esmfold-v1"
        },
        "confidence": 0.52,
        "evidence_note": "derived from mean pLDDT on CA atoms",
        "confidence_band": [
          0.607,
          0.847
        ],
        "not_enough_confidence": true
      },
      {
        "id": "disorder_estimate",
        "label": "disorder estimate",
        "value": 0,
        "source": {
          "model": "PEPFOLD structure heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.52,
        "evidence_note": "estimated from loop proportion and low-confidence structure regions",
        "confidence_band": [
          0,
          0.12
        ],
        "not_enough_confidence": true
      },
      {
        "id": "aggregation_risk",
        "label": "aggregation risk",
        "value": 0.284,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "hydrophobic burden, aromatic burden, charge, and long hydrophobic runs",
        "confidence_band": [
          0.174,
          0.394
        ],
        "not_enough_confidence": false
      },
      {
        "id": "hydrophobic_burden",
        "label": "hydrophobic burden",
        "value": 0.476,
        "source": {
          "model": "PEPFOLD sequence analyzer",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.84,
        "evidence_note": "fraction of hydrophobic residues in sequence",
        "confidence_band": [
          0.436,
          0.516
        ],
        "not_enough_confidence": false
      },
      {
        "id": "charge_distribution_risk",
        "label": "charge distribution risk",
        "value": 0.143,
        "source": {
          "model": "PEPFOLD sequence analyzer",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.84,
        "evidence_note": "absolute net charge normalized by sequence length",
        "confidence_band": [
          0.103,
          0.183
        ],
        "not_enough_confidence": false
      },
      {
        "id": "solubility_risk",
        "label": "solubility risk",
        "value": 0.298,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "composite of aggregation risk, hydrophobic burden, and charge",
        "confidence_band": [
          0.188,
          0.408
        ],
        "not_enough_confidence": false
      },
      {
        "id": "developability_risk",
        "label": "developability risk",
        "value": 0.233,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "composite developability indicator used for triage",
        "confidence_band": [
          0.123,
          0.343
        ],
        "not_enough_confidence": false
      }
    ],
    "generated_at": "2026-06-16T08:43:49.250349+00:00",
    "report_version": "phase-a.v1",
    "sequence_length": 21,
    "synthesis_hints": [],
    "motif_liabilities": [],
    "developability_flags": [],
    "low_confidence_reasons": [
      "DSSP unavailable; secondary structure uses pLDDT fallback."
    ]
  },
  "audit": {
    "input": {
      "sequence_length": 21,
      "sequence_sha256": "b5a7b116ee8ca3b7604e664622bdff1b25141045b6a190092a52894ae7ea8e87"
    },
    "output": {
      "report_sha256": "6f685111831f33de42a2df2d4e4a148284870b3e8b808d6903a2b4b01c393fd5"
    },
    "run_id": "run_d6be91c8727841df902337e41ae43d5b",
    "timestamp": "2026-06-16T08:43:49.250441+00:00",
    "pipeline_versions": {
      "pep_model_version": "claude-opus-4-7",
      "fold_model_version": "esmatlas-esmfold-v1",
      "triage_model_version": "pepfold-triage-v1",
      "secondary_structure_source": "plddt_fallback"
    }
  },
  "attestation": null,
  "next_experiments": {
    "engine": "pepfold-recs-v1",
    "recommendations": []
  },
  "comment": "all loop, zero structure. 21 residues of pure indecision, despite having the hydrophobics to do something interesting. reads like a fragment that forgot what protein it belonged to.",
  "tweet": {
    "id": "2066804253323415836",
    "url": "https://x.com/pepfoldagent/status/2066804253323415836"
  }
}