{
  "report_format_version": "pepfold-report-v1",
  "generated_at": "2026-08-05T05:21:59.705Z",
  "specimen": {
    "number": 199,
    "sequence": "GTLAITGDAEITQFPLDS",
    "sequence_length": 18,
    "status": "complete",
    "wallet": "BWtgNasjEiCX27teVeqcAQEi8iKpt4BTfbFK3e8A5AHK",
    "amount_sol": 0,
    "tx_hash": "2dHJPYCV4cZjgW21xuaLfsix7J5ceU5wrXxYiPidHqeosdLrxat573iD7kV6CF544aFXXYKe1ttj8a1bHbQrZyUV",
    "created_at": "2026-06-16T07:50:15.749267+00:00",
    "completed_at": "2026-06-16T08:35:36.857478+00:00"
  },
  "structure": {
    "pdb_url": "https://mrzziawbddodlpywncfy.supabase.co/storage/v1/object/public/pdb-files/6eea3d42-c851-4078-9f4e-8d944cb3f41d.pdb",
    "helix_pct": 0,
    "sheet_pct": 0,
    "loop_pct": 100
  },
  "triage": {
    "models": {
      "fold_model": {
        "name": "ESMFold",
        "version": "esmatlas-esmfold-v1"
      },
      "triage_model": {
        "name": "PEPFOLD heuristic triage",
        "version": "pepfold-triage-v1"
      },
      "comment_model": {
        "name": "Claude",
        "version": "claude-opus-4-7"
      }
    },
    "run_id": "run_bb7f90600010448b8b48859ef41395f9",
    "metrics": [
      {
        "id": "fold_confidence",
        "label": "fold confidence",
        "value": 0.721,
        "source": {
          "model": "ESMFold",
          "version": "esmatlas-esmfold-v1"
        },
        "confidence": 0.52,
        "evidence_note": "derived from mean pLDDT on CA atoms",
        "confidence_band": [
          0.601,
          0.841
        ],
        "not_enough_confidence": true
      },
      {
        "id": "disorder_estimate",
        "label": "disorder estimate",
        "value": 0.222,
        "source": {
          "model": "PEPFOLD structure heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.52,
        "evidence_note": "estimated from loop proportion and low-confidence structure regions",
        "confidence_band": [
          0.102,
          0.342
        ],
        "not_enough_confidence": true
      },
      {
        "id": "aggregation_risk",
        "label": "aggregation risk",
        "value": 0.271,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "hydrophobic burden, aromatic burden, charge, and long hydrophobic runs",
        "confidence_band": [
          0.161,
          0.381
        ],
        "not_enough_confidence": false
      },
      {
        "id": "hydrophobic_burden",
        "label": "hydrophobic burden",
        "value": 0.389,
        "source": {
          "model": "PEPFOLD sequence analyzer",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.84,
        "evidence_note": "fraction of hydrophobic residues in sequence",
        "confidence_band": [
          0.349,
          0.429
        ],
        "not_enough_confidence": false
      },
      {
        "id": "charge_distribution_risk",
        "label": "charge distribution risk",
        "value": 0.167,
        "source": {
          "model": "PEPFOLD sequence analyzer",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.84,
        "evidence_note": "absolute net charge normalized by sequence length",
        "confidence_band": [
          0.127,
          0.207
        ],
        "not_enough_confidence": false
      },
      {
        "id": "solubility_risk",
        "label": "solubility risk",
        "value": 0.276,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "composite of aggregation risk, hydrophobic burden, and charge",
        "confidence_band": [
          0.166,
          0.386
        ],
        "not_enough_confidence": false
      },
      {
        "id": "developability_risk",
        "label": "developability risk",
        "value": 0.264,
        "source": {
          "model": "PEPFOLD developability heuristic",
          "version": "pepfold-triage-v1"
        },
        "confidence": 0.56,
        "evidence_note": "composite developability indicator used for triage",
        "confidence_band": [
          0.154,
          0.374
        ],
        "not_enough_confidence": false
      }
    ],
    "generated_at": "2026-06-16T08:34:16.874953+00:00",
    "report_version": "phase-a.v1",
    "sequence_length": 18,
    "synthesis_hints": [],
    "motif_liabilities": [],
    "developability_flags": [],
    "low_confidence_reasons": [
      "DSSP unavailable; secondary structure uses pLDDT fallback."
    ]
  },
  "audit": {
    "input": {
      "sequence_length": 18,
      "sequence_sha256": "2698162e0d9d88b0e17217f460bb802f8c8f766e67ae4a24dd98e8b95caa9c75"
    },
    "output": {
      "report_sha256": "adccdf3dc898521b3c7f7510b6e60bfbb2e6707f1a5254b44944da35199666e4"
    },
    "run_id": "run_bb7f90600010448b8b48859ef41395f9",
    "timestamp": "2026-06-16T08:34:16.875045+00:00",
    "pipeline_versions": {
      "pep_model_version": "claude-opus-4-7",
      "fold_model_version": "esmatlas-esmfold-v1",
      "triage_model_version": "pepfold-triage-v1",
      "secondary_structure_source": "plddt_fallback"
    }
  },
  "attestation": null,
  "next_experiments": {
    "engine": "pepfold-recs-v1",
    "recommendations": []
  },
  "comment": "all loop, no commitment. 18 residues that just drift, no helix or sheet trying to assert itself. reads like a flexible linker that got separated from whatever it was supposed to connect.",
  "tweet": {
    "id": "2066801856861688198",
    "url": "https://x.com/pepfoldagent/status/2066801856861688198"
  }
}